Protecting your pet against heartworm disease – and making sure that roundworms and hookworms are treated and controlled – involves simple, convenient, once-a-month administration of HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables. To help ensure your dog gets its HEARTGARD Plus treatment on time at regular monthly intervals, take advantage of our FREE monthly email Reminder Service. It just takes a moment to sign up.